(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

Base Information

Chemical Name:(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]
CAS No.:1350803-17-6
Molecular Formula:C₃₀H₃₄O₄S
Molecular Weight:490.664
Hs Code.:

Synonyms:(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

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Chemical Property of (2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

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Technology Process of (2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

There total 9 articles about (2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1350803-10-9
(2S,4S)-4-methyl-5-methylene-2-phenethyl-1,3-dioxolane

: 1350803-16-5
tert-butyl (2-(1-hydroxy-3-(phenylthio)propyl)-4-methoxy-5-methylphenyl) carbonate

: 1350803-17-6
(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

Guidance literature:: With methylmagnesium bromide; In diethyl ether; at -78 - 20 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/jo201971g

Reference yield:

: 183322-78-3
(2S,5S)-5-methyl-2-phenethyl-1,3-dioxolan-4-one

: 1350803-17-6
(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 1.5 h / 20 - 78 °C / Inert atmosphere

2: methylmagnesium bromide / diethyl ether / 3 h / -78 - 20 °C / Inert atmosphere

With methylmagnesium bromide; In diethyl ether; toluene;
DOI:10.1021/jo201971g

Reference yield:

: 1350803-14-3
1-(2-Hydroxy-5-methoxy-4-methylphenyl)-3-(phenylthio)propan-1-one

: 1350803-17-6
(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / tetrahydrofuran; water / 0 °C

3: methylmagnesium bromide / diethyl ether / 3 h / -78 - 20 °C / Inert atmosphere

With dmap; sodium tetrahydroborate; methylmagnesium bromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jo201971g