(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

Base Information

Chemical Name:(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol
CAS No.:1350803-18-7
Molecular Formula:C₂₁H₂₆O₃S
Molecular Weight:358.502
Hs Code.:

Synonyms:(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

Chemical Property:

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Technology Process of (S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

There total 8 articles about (S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1350803-17-6
(2R,2'S,4S,5'S)-6-methoxy-5',7-dimethyl-2'-phenethyl-4-(2-(phenylthio)ethyl)spiro[chroman-2,4'-[1,3]dioxolane]

: 1350803-18-7
(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at -78 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo201971g

Reference yield:

: 1350803-25-6
C₂₂H₂₆O₅S

: 1350803-18-7
(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; water / 0 °C

2: methylmagnesium bromide / diethyl ether / 3 h / -78 - 20 °C / Inert atmosphere

3: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

With triethylsilane; sodium tetrahydroborate; boron trifluoride diethyl etherate; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jo201971g

Reference yield:

: 1350803-16-5
tert-butyl (2-(1-hydroxy-3-(phenylthio)propyl)-4-methoxy-5-methylphenyl) carbonate

: 1350803-18-7
(S)-1-((2R,4S)-6-methoxy-7-methyl-4-(2-(phenylthio)ethyl)chroman-2-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: methylmagnesium bromide / diethyl ether / 3 h / -78 - 20 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; methylmagnesium bromide; In diethyl ether; dichloromethane;
DOI:10.1021/jo201971g