(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

Base Information

Chemical Name:(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride
CAS No.:1354492-73-1
Molecular Formula:C₂₁H₂₃NO₇*ClH
Molecular Weight:437.877
Hs Code.:

Synonyms:(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

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Chemical Property of (2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

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Technology Process of (2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

There total 5 articles about (2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1353745-58-0
(S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

: 1354492-73-1
(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid; In water; at 45 ℃; for 3h;
DOI:10.1039/c1cc15135e

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 1354492-73-1
(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2: phenyliodine bis(trifluoroacetate) / acetonitrile / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / Inert atmosphere

4: hydrogenchloride; acetic acid / water / 3 h / 45 °C

With hydrogenchloride; dmap; n-butyllithium; phenyliodine bis(trifluoroacetate); acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1039/c1cc15135e

Reference yield:

: 5425-44-5
2-Phenyl-[1,3]dithiane

: 1354492-73-1
(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2: phenyliodine bis(trifluoroacetate) / acetonitrile / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / Inert atmosphere

4: hydrogenchloride; acetic acid / water / 3 h / 45 °C

With hydrogenchloride; dmap; n-butyllithium; phenyliodine bis(trifluoroacetate); acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1039/c1cc15135e