(S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

Base Information

• Chemical Name: (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate
• CAS No.: 1353745-58-0
• Molecular Formula: C₃₀H₃₉NO₉
• Molecular Weight: 557.641

Synonyms:(S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

Chemical Property of (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

There total 4 articles about (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one (34904-92-2) + N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) → (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate (1353745-58-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Inert atmosphere;

DOI:10.1039/c1cc15135e

Reference yield:

2-Phenyl-[1,3]dithiane (5425-44-5) → (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate (1353745-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2: phenyliodine bis(trifluoroacetate) / acetonitrile / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / Inert atmosphere

With dmap; n-butyllithium; phenyliodine bis(trifluoroacetate); dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1039/c1cc15135e

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate (1353745-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran / Inert atmosphere

2: phenyliodine bis(trifluoroacetate) / acetonitrile / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / Inert atmosphere

With dmap; n-butyllithium; phenyliodine bis(trifluoroacetate); dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1039/c1cc15135e

upstream raw materials:

2-Phenyl-[1,3]dithiane

2-(3,5-dimethoxyphenyl)-2-hydroxy-1-phenylethan-1-one

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

3,5-dimethoxybenzaldehdye

Downstream raw materials:

(2S)-amino-5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethoxy]-5-oxopentanoic acid hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1353745-58-0 (S)-1-tert-butyl 5-[(RS)-1-(3,5-dimethoxyphenyl)-2-oxo-2-phenylethyl] 2-(tert-butoxycarbonylamino)pentanedioate

Send

Send

Metric Ton KG G Pound L ML

Send

Send