4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine

Base Information

• Chemical Name: 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine
• CAS No.: 862534-99-4
• Molecular Formula: C₁₉H₁₀ClN₅S
• Molecular Weight: 375.841
• Mol file: 862534-99-4.mol

Synonyms:4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine

Chemical Property of 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine

There total 4 articles about 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-one (173723-18-7) → 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine (862534-99-4)

Guidance literature:

With trichlorophosphate; for 3h; Heating;

DOI:10.1080/104265090517398

Reference yield:

ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbohydrazide (128462-42-0) → 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine (862534-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / aq. H₂NNH₂ / ethanol / 2 h / Heating

2: 86 percent / NaNO₂; aq. AcOH / 5 - 10 °C

3: 42 percent / POCl₃ / 3 h / Heating

With hydrazine hydrate; acetic acid; sodium nitrite; trichlorophosphate; In ethanol;

DOI:10.1080/104265090517398

Reference yield:

5-amino-3,4-diphenylthieno<2,3-c>pyridazine-6-carboxamide (135127-78-5) → 4-chloro-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine (862534-99-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 83.5 percent / NaNO₂; aq. AcOH / 5 - 15 °C

2: 42 percent / POCl₃ / 3 h / Heating

With acetic acid; sodium nitrite; trichlorophosphate;

DOI:10.1080/104265090517398

upstream raw materials:

8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazin-4(3H)-one

ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbohydrazide

5-amino-3,4-diphenylthieno<2,3-c>pyridazine-6-carboxamide

3-amino-4,5-diphenylthieno[2,3-c]pyridazine-2-carbohydrazide

Downstream raw materials:

4-hydrazino-8,9-diphenylpyridazino[4',3':4,5]thieno[3,2-d]-1,2,3-triazine