128462-42-0

Upstream product

• 112450-34-7 4-cyano-5,6-diphenylpyridazine-3 (2H)-thione 
• 105-39-5 chloroacetic acid ethyl ester 
• 94011-79-7 3-chloro-5,6-diphenylpyridazine-4-carbonitrile 
• 623-51-8 ethyl 2-sulfanylacetate 
• 112450-34-7 4-cyano-5,6-diphenylpyridazin-3(2H)-thione 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 159698-27-8 ethyl 5-(1-pyrrolyl)-3,4-diphenylthieno<2,3-c>pyridazine-6-carboxylate 
• 194546-63-9 ethyl 3,4-diphenyl-5-(triphenylphosphoranilydeneamino)thieno[2,3-c]pyridazine-6-carboxylate 
• 321602-53-3 3-amino-4,5-diphenyl-2-[N-(2-hydroxyethyl)]carbamoylthieno[2,3-c]pyridazine 
• 135127-79-6 8,9-diphenylpyrimido<4',5':4,5>thieno<2,3-c>pyridazin-4(3H)-one 
• 393129-62-9 ethyl 5-ethoxycarbonylamino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate 
• 850075-65-9 ethyl 5-acetylamino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate 
• 872057-83-5 2-methyl-8,9-diphenyl-4H-pyridazino[4',3':4,5]thieno[3,2-d]-1,3-oxazin-4-one 
• 914650-31-0 ethyl 5-chloroacetylamino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate 
• 914650-69-4 N-(6-ethoxycarbonyl-3,4-diphenylthieno[2,3-c]pyridazin-5-yl)-N'-benzoylthiourea 
• 887510-73-8 5-chloro-12,13-diphenylpyridazino[3'',4'':5',4']thieno[3',2':4,5]pyrido[2,1-a]phthalazin-8-one 
• 887510-77-2 5-mercapto-12,13-diphenylpyridazino[3'',4'':5',4']thieno[3',2':4,5]pyrido[2,1-a]phthalazin-8-one 
• 887510-72-7 12,13-diphenyl-6H-pyridazino[3'',4'':5',4']thieno[3',2':4,5]pyrido[2,1-a]phthalazin-5,8-dione 

Relevant academic research and scientific papers

The first synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives

We report a five step method for the synthesis of furo[2,3-c]pyridazin-4(1H)-one derivatives representing a novel heteroaromatic ring-system. The first synthesis of 3-carboxylic and methyl-3-carboxylate derivatives of the 1-phenyl and 1-(p-methoxyphenyl) compounds are reported.

Pyridazine derivatives and related compounds. Part 11: 1Synthesis of some pyrimido[4′,5′:4,5]thieno[2,3-c] pyridazines

3-Substituted pyrimido[4′,5′:4,5]thieno[2,3-c/pyridazine-2,4- di-ones and 3-amino-2-methylpyrimido[4′,5′:4,5]thieno[2,3-c] pyridazine-4-ones were synthesized starting from ethyl 5-aminothieno[2,3-c] pyridazine-6-carboxylate 1. Reaction of amino ester 1 with phenyl isothiocyanate affords thiourea derivative 10 which undergo further transformation to the related fused heterocyclic systems.

An efficient synthesis for pyrimido[4′,5′:4,5]-thieno[2,3-c]pyridazine derivatives via intramolecular AZA-wittig reaction-heterocyclization strategy

A ready one-pot preparation for substituted pyrimidothienopyridazines is reported. Aza-Wittig reaction of iminophosphorane (3), derived from ethyl 5-amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carboxylate (2), with isocyanates, followed by heterocyclization on addition of amines provided a novel synthetic route to the functionalized pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazines (6). The guanidine-type intermediate compounds (5) derived from addition of amines to the carbodiimides (4) could be isolated and characterized, thus confirming the suggest reaction pathway.