N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Base Information

Chemical Name:N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester
CAS No.:126016-78-2
Molecular Formula:C₂₄H₃₁N₅O₆
Molecular Weight:485.54
Hs Code.:

Synonyms:N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

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Chemical Property of N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

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Technology Process of N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

There total 17 articles about N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 243636-57-9
diethyl N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7-(α-methylbenzyl)pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate

: 126016-78-2
N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃; for 72h; under 2844.39 Torr;
DOI:10.1021/jo001580l

Reference yield:

: chloro-dimethoxy-triazine

: CH₂ Cl₂ -EtOH

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 151723-87-4
4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoic acid

: 126016-78-2
N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: With 4-methyl-morpholine; NMM; In N-methyl-acetamide;

Reference yield:

: 243636-52-4
1-(α-methylbenzyl)-3-methoxycarbonyl-4-vinyl-2-pyrrolidinone

: 126016-78-2
N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 68 percent / P₄S₁₀ / tetrahydrofuran / 2.5 h / Heating

2.1: NaOMe / methanol / 0.5 h / 20 °C

2.2: 50 percent / methanol / 1 h / 90 °C / 15 Torr

3.1: 68 percent / Et₃N; CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 48 h / 75 °C

4.1: 6 percent / H₂ / Pd/C / methanol / 72 h / 50 °C / 2844.39 Torr

With copper(l) iodide; tetraphosphorus decasulfide; hydrogen; sodium methylate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 3.1: Heck reaction;
DOI:10.1021/jo001580l