151723-87-4

Upstream product

• 50-01-1 guanidine hydrochloride 
• 120363-13-5 tert-butyl 4-iodobenzoate 
• 153170-76-4 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 
• 153170-70-8 2-ethylcarboxy-3-nitromethyl-5-(4-(2,2-dimethylethyl)carboxyphenyl)pentanoic acid ethyl ester 
• 153170-75-3 4-<2-(2-thiocarbonyl-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid 2,2-dimethylethyl ester 
• 153170-71-9 4-<2-(2-oxo-3-carboethoxypyrrolidin-4-yl)ethyl>benzoic acid, 2,2-dimethylethyl ester 
• 151723-79-4 2-ethylcarboxy-5-(4-(2,2-dimethylethyl)carboxyphenyl)-2-pentenoic acid ethyl ester 
• 134372-99-9 3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal 

Downstream Products

• 126016-78-2 N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester 

Relevant academic research and scientific papers

Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines

This invention relates to intermediates and processes thereto, for the preparation of 5,6-dihydropyrro[2,3-d]pyrimidines which are useful for the treatment of susceptible neoplasms

SYNTHESIS OF LY288601, A 5,6-DIHYDROPYRROLOPYRIMIDINE BASED ANTIFOLATE COMPOUND RELATED TO LY231514

An expeditious synthesis of LY288601 (2), the 5,6-dihydro analog of the pyrrolopyrimidine-based antifolate compound LY231514 (1a), is described.The synthesis proceeds in eight steps from tert-butyl 4-iodobenzoate and involves the elaboration of a 2