(2-Fluoro-phenyl)-methanesulfonyl chloride

Base Information

• Chemical Name: (2-Fluoro-phenyl)-methanesulfonyl chloride
• CAS No.: 24974-71-8
• Molecular Formula: C7H6ClFO2S
• Molecular Weight: 208.641
• Hs Code.: 2904990090
• Mol file: 24974-71-8.mol

Synonyms:a-Toluenesulfonylchloride, o-fluoro- (8CI);(2-Fluorobenzyl)sulfonyl chloride;

Chemical Property of (2-Fluoro-phenyl)-methanesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.00393mmHg at 25°C
• Melting Point: 55 °C
• Refractive Index: 1.546
• Boiling Point: 288.97 °C at 760 mmHg
• Flash Point: 128.565 °C
• PSA: 42.52000
• Density: 1.465 g/cm³
• LogP: 2.97510

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2-Fluorophenyl)methanesulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C; Xi
• Hazard Codes: C,Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-Fluoro-phenyl)-methanesulfonyl chloride

There total 3 articles about (2-Fluoro-phenyl)-methanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

2-fluorobenzyl thiouronium hydrochloride → (2-fluorophenyl)methanesulfonyl chloride (24974-71-8)

Guidance literature:

With chlorine; In water; at -5 - 5 ℃; Cooling with acetone-dry ice;

Reference yield:

2-fluorobenzyl chloride (345-35-7) → (2-fluorophenyl)methanesulfonyl chloride (24974-71-8)

Guidance literature:

2-fluorobenzyl chloride; With thiourea; In ethanol; at 96 ℃;

With hydrogenchloride; In water; acetonitrile; at 0 ℃; for 0.25h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃;

DOI:10.1002/anie.201701579

Reference yield:

→ (2-fluorophenyl)methanesulfonyl chloride (24974-71-8)

Guidance literature:

o-F-C6H4-CH2-Hal, 1) Na2SO3, 2) PCl5;

upstream raw materials:

2-fluorobenzyl chloride

Downstream raw materials:

(2-fluorophenyl)methanesulfonamide

Refernces

• 1、 Kong, Deyu,Xue, Tao,Guo, Bin,Cheng, Jianjun,Liu, Shunyin,Wei, Jianhai,Lu, Zhengyu,Liu, Haoran,Gong, Guoqing,Lan, Tian,Hu, Wenhao,Yang, Yushe. "Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties". supporting information. p. 3088 - 3106. Retrieved 2019/04/01.
• 2、 Bera, Milan,Agasti, Soumitra,Chowdhury, Rajdip,Mondal, Rahul,Pal, Debasis,Maiti, Debabrata. "Rhodium-Catalyzed meta-C?H Functionalization of Arenes". supporting information. p. 5272 - 5276. Retrieved 2017/04/27.