2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Base Information

Chemical Name:2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione
CAS No.:1425943-07-2
Molecular Formula:C₂₇H₁₇Cl₃F₃NO₃
Molecular Weight:566.791
Hs Code.:

Synonyms:2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Suppliers and Price of 2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

There total 7 articles about 2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₁₉Cl₃F₃NO₄

: 1425943-07-2
2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: With toluene-4-sulfonic acid; In hexane; for 6h; under 37503.8 Torr; Reflux;

Reference yield:

: 85-44-9
phthalic anhydride

: 1425943-07-2
2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / Reflux

2: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); sodium acetate / N,N-dimethyl acetamide / 0.5 h / 175 - 200 °C / Inert atmosphere; Microwave irradiation

3: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / toluene / 16 h / 100 °C / 37503.8 Torr

4: toluene-4-sulfonic acid / hexane / 6 h / 37503.8 Torr / Reflux

With trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; sodium acetate; toluene-4-sulfonic acid; In hexane; N,N-dimethyl acetamide; acetic acid; toluene;

Reference yield:

: 1425943-06-1
2-[(1S)-1-[4-[(E)-4,4,4-trifluoro-3-hydroxy-3-(3,4,5-trichlorophenyl)but-1-enyl]phenyl]ethyl]isoindoline-1,3-dione

: 1425943-07-2
2-[(1S)-1-[4-[2-(3,4,5-trichlorophenyl)-2-(trifluoromethyl)-3H-furan-4-yl]phenyl]ethyl]isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen / toluene / 16 h / 100 °C / 37503.8 Torr

2: toluene-4-sulfonic acid / hexane / 6 h / 37503.8 Torr / Reflux

With dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; toluene-4-sulfonic acid; In hexane; toluene;