Technology Process of 7-{2'-[4''-(aminoethyl)phenylcarbamoyl]ethyl}-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
There total 13 articles about 7-{2'-[4''-(aminoethyl)phenylcarbamoyl]ethyl}-1,3-dihydro-1-hydroxy-2,1-benzoxaborole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl)-N-(4-((tert-butoxycarbonyl)aminomethyl)phenyl)propanamide;
With
hydrogenchloride;
In
methanol;
at 20 - 25 ℃;
for 6h;
With
sodium hydroxide;
In
water;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: silica gel; pyridinium chlorochromate / dichloromethane / 20 - 25 °C
2.1: toluene-4-sulfonic acid / toluene / Reflux
2.2: 2 h / Reflux
3.1: sodium tetrahydroborate / methanol / 1 h / 20 - 25 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / 20 - 25 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 °C
5.2: -78 - 25 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 20 h / 20 - 25 °C
7.1: hydrogen / platinum(IV) oxide trihydrate / methanol / 20 - 25 °C
8.1: sodium hydroxide; water / methanol / 1 h / Reflux
8.2: pH 2 / Acidic conditions
9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 25 °C
10.1: hydrogenchloride / methanol / 6 h / 20 - 25 °C
With
hydrogenchloride; sodium tetrahydroborate; n-butyllithium; water; hydrogen; silica gel; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; sodium hydroxide;
platinum(IV) oxide trihydrate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; toluene; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate / methanol / 1 h / 20 - 25 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 7 h / 20 - 25 °C
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 °C
3.2: -78 - 25 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 20 h / 20 - 25 °C
5.1: hydrogen / platinum(IV) oxide trihydrate / methanol / 20 - 25 °C
6.1: sodium hydroxide; water / methanol / 1 h / Reflux
6.2: pH 2 / Acidic conditions
7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 25 °C
8.1: hydrogenchloride / methanol / 6 h / 20 - 25 °C
With
hydrogenchloride; sodium tetrahydroborate; n-butyllithium; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
platinum(IV) oxide trihydrate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; mineral oil;
