(S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

Base Information

• Chemical Name: (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate
• CAS No.: 1390672-89-5
• Molecular Formula: C₃₉H₄₀N₂O₆
• Molecular Weight: 632.756

Synonyms:(S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

Chemical Property of (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

There total 3 articles about (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Fmoc-Pro-OH (71989-31-6) + ((1S,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-carbamic acid tert-butyl ester (259539-75-8) → (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate (1390672-89-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 25h;

DOI:10.1039/c2ob25693b

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate (1390672-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 25 h / 0 - 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 25 h / 0 - 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/c2ob25693b

Reference yield:

(1S,2S)-2-amino-1,2-diphenylethanol (530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0) → (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate (1390672-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 25 h / 0 - 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 25 h / 0 - 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/c2ob25693b

upstream raw materials:

di-tert-butyl dicarbonate

(1S,2S)-2-amino-1,2-diphenylethanol

Fmoc-Pro-OH

((1S,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-carbamic acid tert-butyl ester

Downstream raw materials:

(S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(3-((S)-1,4-di-tert-butoxy-1,4-dioxobutan-2-yl)thioureido)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

(S)-di-tert-butyl 2-(3-((1S,2S)-1,2-diphenyl-2-((S)-pyrrolidine-2-carbonyloxy)ethyl)thioureido)succinate

C₂HF₃O₂*C₃₄H₃₂N₂O₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1390672-89-5 (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send