259539-75-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 530-36-9 (1S,2S)-2-amino-1,2-diphenylethanol 
• 170080-05-4 (4S,5S)-4,5-diphenyl-2-oxazolidinone 
• 259539-62-3 (4S,5S)-3-Benzoyl-4,5-diphenyl-oxazolidin-2-one 
• 2325-10-2 (S,S)-hydrobenzoin 
• 253350-13-9 (4S,5S)-2-Oxo-4,5-diphenyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 1390672-93-1 (S)-di-tert-butyl 2-(3-((1S,2S)-1,2-diphenyl-2-((S)-pyrrolidine-2-carbonyloxy)ethyl)thioureido)succinate 
• 1390672-92-0 (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(3-((S)-1,4-di-tert-butoxy-1,4-dioxobutan-2-yl)thioureido)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate 
• 1390672-91-9 C₂HF₃O₂*C₃₄H₃₂N₂O₄ 
• 1390672-89-5 (S)-1-(9H-fluoren-9-yl)methyl 2-((1S,2S)-2-(tert-butoxycarbonylamino)-1,2-diphenylethyl)pyrrolidine-1,2-dicarboxylate 
• 530-36-9 (1S,2S)-2-amino-1,2-diphenylethanol 

Relevant academic research and scientific papers

A tripeptide-like prolinamide-thiourea as an aldol reaction catalyst

A tripeptide-like prolinamide-thiourea catalyst with (S)-proline, (1S,2S)-diphenylethylenediamine and (S)-di-tert-butyl aspartate as building blocks provides the products of the reaction between ketones and aromatic aldehydes in high to quantitative yields and high stereoselectivities (up to 99:1 dr and 99% ee). Both the chiral centers of the diamine unit are essential, while the thiourea hydrogen originating from the amine and the amide hydrogen play a predominant role for the catalyst efficiency.