(S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one

Base Information

• Chemical Name: (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one
• CAS No.: 256389-69-2
• Molecular Formula: C₁₉H₂₁NO₂
• Molecular Weight: 295.381
• Mol file: 256389-69-2.mol

Synonyms:(S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one

Chemical Property of (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one

There total 15 articles about (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) + (S)-3-(4-Methoxy-phenyl)-3-methyl-pyrrolidin-2-one (317817-87-1) → (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one (256389-69-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1016/S0040-4039(00)01471-4

Reference yield:

(3S,7aR)-6-(4-Methoxy-phenyl)-6-methyl-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one → (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one (256389-69-2)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃SiH; TiCl₄ / CH₂Cl₂ / 0 °C

2: PPh₃; CCl₄ / CH₂Cl₂ / Heating

3: DBU / toluene / Heating

4: aq. HCl / methanol / 20 °C

5: NaH / dimethylformamide / 0 °C

With hydrogenchloride; triethylsilane; tetrachloromethane; titanium tetrachloride; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Ring cleavage / 2: Substitution / 3: Dehydrochlorination / 4: Hydrolysis / 5: benzylation;

DOI:10.1016/S0040-4039(00)01471-4

Reference yield:

(S)-3-(4-Methoxy-phenyl)-3-methyl-1-(1-phenyl-vinyl)-pyrrolidin-2-one → (S)-1-Benzyl-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one (256389-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / methanol / 20 °C

2: NaH / dimethylformamide / 0 °C

With hydrogenchloride; sodium hydride; In methanol; N,N-dimethyl-formamide; 1: Hydrolysis / 2: benzylation;

DOI:10.1016/S0040-4039(00)01471-4

upstream raw materials:

(S)-4-Benzylamino-2-(4-methoxy-phenyl)-2-methyl-butyric acid methyl ester

benzyl bromide

(S)-3-(4-Methoxy-phenyl)-3-methyl-pyrrolidin-2-one

(S)-1-((S)-2-Hydroxy-1-phenyl-ethyl)-3-(4-methoxy-phenyl)-3-methyl-pyrrolidin-2-one