(R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate

Base Information

• Chemical Name: (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate
• CAS No.: 326603-45-6
• Molecular Formula: C₁₇H₂₄O₄
• Molecular Weight: 292.375
• Mol file: 326603-45-6.mol

Synonyms:(R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate

Chemical Property of (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate

There total 2 articles about (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-enoate (326603-41-2) → (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate (326603-45-6)

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; at -50 ℃;

DOI:10.1055/s-2007-1000868

Reference yield:

methyllithium (917-54-4) + ethyl (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-enoate (326603-41-2) → (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate (326603-45-6) + ethyl (3S)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate (326603-47-8)

Guidance literature:

methyllithium; With copper(l) iodide; In diethyl ether; toluene; at -78 - -40 ℃; for 0.25h;

With boron trifluoride diethyl etherate; In diethyl ether; toluene; at -78 ℃; for 0.25h;

ethyl (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-enoate; In diethyl ether; toluene; at -78 ℃; for 16h; Further stages. Title compound not separated from byproducts.;

DOI:10.1055/s-2007-1000868

Reference yield: 71.0%

(R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate (326603-45-6) → (3R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-2-hydroxybutanoate

Guidance literature:

With MoO₅*pyridine*HMPA; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1055/s-2007-1000868

upstream raw materials:

methyllithium

ethyl (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-enoate