326603-41-2

Upstream product

• 77-76-9 2,2-dimethoxy-propane 
• 161807-50-7 (2E,4R,5R)-4,5-dihydroxy-5-phenylpent-2-enoic acidethylester 
• 39806-16-1 ethyl (2E,4E)-5-phenyl-penta-2,4-dienoate 

Downstream Products

• 371978-06-2 (E)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]prop-2-en-1-ol 
• 326603-45-6 (R)-ethyl 3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate 
• 326603-47-8 ethyl (3S)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]butanoate 
• 270901-32-1 (E)-(3S,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6,6-dimethyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 186256-67-7 cryptophycin 52 
• 196794-26-0 (E)-(3S,6R,10R,16S)-10-(3-Chloro-4-methoxy-benzyl)-16-((1R,2R,3R)-2,3-dihydroxy-1-methyl-3-phenyl-propyl)-3-isobutyl-6-methyl-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 124689-65-2 cryptophycin-1 
• 866343-45-5 (E)-(5S,6S)-5-((S)-2-{(R)-3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2-methyl-propionyloxy}-4-methyl-pentanoyloxy)-6-((4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-hept-2-enoic acid tert-butyl ester 
• 866343-67-1 (E)-(5S,6S)-5-((S)-2-{3-[(R)-2-tert-Butoxycarbonylamino-3-(3-chloro-4-methoxy-phenyl)-propionylamino]-2,2-dimethyl-propionyloxy}-4-methyl-pentanoyloxy)-6-((4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-hept-2-enoic acid tert-butyl ester 
• 866343-53-5 (2R,3S)-2-(allyloxy)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-butyl 4-methylbenzenesulfonate 
• 866343-61-5 (2S,3S)-2-(allyoxy)-3-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-butyl 4-methylbenzenesulfonate 
• 866343-51-3 tert-butyl (5S,6S,E)-5-(allyloxy)-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-hept-2-enoate 
• 866343-64-8 tert-butyl (5R,6S,E)-5-(allyloxy)-[(4R,5R)-2,2-dimethyl-5-phenyl-1,3-dioxolan-4-yl]-hept-2-enoate 
• 866343-48-8 (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxy)-3-((4R,5R)-2,2-dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-butyric acid ethyl ester 

Relevant academic research and scientific papers

A simple and efficient total synthesis of a styryllactone, 7-epi-goniodiol

Regioselective mono-dihydroxylation, Red-Al reduction, and cis-Horner-Wadsworth-Emmons reactions have been efficiently performed as key steps in the synthesis of 7-epi-goniodiol, isolated from Goniothalamus leiocarpus. Georg Thieme Verlag Stuttgart.

Efficient and versatile stereoselective synthesis of cryptophycins

The cryptophycins are a family of cyclic depsipeptides with four retrosynthetic units A to D which correspond to the respective amino acids and hydroxy acids. A new synthetic route to unit A allows the selective generation of all four stereogenic centres

Control of diastereofacial discrimination in the conjugate addition to 5-phenyl-1,3-dioxolan-4-yl substituted propenoate

The conjugate addition of methylcuprates and methyllithium to ethyl 5-phenyl-1,3-dioxolan-4-yl-2-propenoate was investigated. It was found that the stereoselectivity is highly dependent on the reagent used. In reactions with stabilized methylcuprates, the