6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

Base Information

Chemical Name:6-(3,4-difluorophenyl)-5-fiuoropicolinic acid
CAS No.:1210418-85-1
Molecular Formula:C₁₂H₆F₃NO₂
Molecular Weight:253.18
Hs Code.:

Synonyms:6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

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Chemical Property of 6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

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Technology Process of 6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

There total 3 articles about 6-(3,4-difluorophenyl)-5-fiuoropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1052714-46-1
6-bromo-5-fluoro-pyridine-2-carboxylic acid

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 1210418-85-1
6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield: 70.0%

: 1210418-85-1
6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

Guidance literature:

Reference yield:

: 374633-36-0
2-bromo-3-fluoro-6-methylpyridine

: 1210418-85-1
6-(3,4-difluorophenyl)-5-fiuoropicolinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium permanganate / water / 53 h / 100 °C

2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.5 h / 120 °C / Microwave irradiation

With potassium permanganate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,2-dimethoxyethane; water;