2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

Base Information

Chemical Name:2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid
CAS No.:1616372-61-2
Molecular Formula:C₃₂H₃₉N₅O₄
Molecular Weight:557.693
Hs Code.:

Synonyms:2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

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Chemical Property of 2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

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Technology Process of 2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

There total 9 articles about 2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1616373-15-9
2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetonitrile

: 1616372-61-2
2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

Guidance literature:: With water; potassium hydroxide; In ethylene glycol; at 120 ℃; for 16h;

Reference yield:

: 1616373-11-5
ethyl 4-(2-chloropyrimidin-4-yl)butanoate

: 1616372-61-2
2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 85 °C / Inert atmosphere; Sealed tube

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

3.2: 16 h / 20 °C

4.1: camphor-10-sulfonic acid / ethyl acetate / 16 h / Reflux

5.1: potassium hydroxide; water / ethylene glycol / 16 h / 120 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; ethylene glycol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1616373-13-7
4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoic acid

: 1616372-61-2
2-(5-(4-(3-(1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)pyrimidin-2-yl)-2-ethoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

1.2: 16 h / 20 °C

2.1: camphor-10-sulfonic acid / ethyl acetate / 16 h / Reflux

3.1: potassium hydroxide; water / ethylene glycol / 16 h / 120 °C

With camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In ethylene glycol; ethyl acetate; N,N-dimethyl-formamide;