1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

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Chemical Name:1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide
CAS No.:1616373-14-8
Molecular Formula:C₃₂H₄₀N₆O₃
Molecular Weight:556.708
Hs Code.:

Synonyms:1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

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Chemical Property of 1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

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Technology Process of 1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

There total 6 articles about 1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454928-30-3
1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide monomethanesulfonate

: 1616373-13-7
4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoic acid

: 1616373-14-8
1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

Guidance literature:: 4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h;

1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide monomethanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1616373-11-5
ethyl 4-(2-chloropyrimidin-4-yl)butanoate

: 1616373-14-8
1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 16 h / 85 °C / Inert atmosphere; Sealed tube

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

3.2: 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1616373-12-6
ethyl 4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoate

: 1616373-14-8
1-(4-(tert-butyl)benzyl)-2-(4-(2-(3-(cyanomethyl)-4-ethoxyphenyl)pyrimidin-4-yl)butanoyl)-N-ethylhydrazinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 1.5 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.67 h / 20 °C

2.2: 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;