3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

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Chemical Name:3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester
CAS No.:247017-91-0
Molecular Formula:C₅₄H₅₀N₃O₁₂P
Molecular Weight:963.978
Hs Code.:

3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

Synonyms:3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

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Chemical Property of 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

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Technology Process of 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

There total 3 articles about 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 247017-86-3
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid iodomethyl ester

: ((4-(((bis(benzyloxy)phosphoryl)oxy)methyl)benzoyl)oxy)silver

: 247017-91-0
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

Guidance literature:: In toluene; Heating;
DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

: 158991-23-2
PD 154075

: 247017-91-0
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KN(TMS)2 / tetrahydrofuran / -78 °C

1.2: 99 percent / tetrahydrofuran / -78 °C

2.1: 97 percent / NaI / acetone / Heating

3.1: 75 percent / toluene / Heating

With potassium hexamethylsilazane; sodium iodide; In tetrahydrofuran; acetone; toluene; 1.1: Metallation / 1.2: Acylation / 2.1: Iodination / 3.1: Substitution;
DOI:10.1016/S0960-894X(00)00183-9

Reference yield:

: 247017-85-2
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester

: 247017-91-0
3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / NaI / acetone / Heating

2: 75 percent / toluene / Heating

With sodium iodide; In acetone; toluene; 1: Iodination / 2: Substitution;
DOI:10.1016/S0960-894X(00)00183-9