1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

Base Information

Chemical Name:1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester
CAS No.:1033766-32-3
Molecular Formula:C₂₅H₃₅N₅O₇S₂
Molecular Weight:581.714
Hs Code.:

1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

Synonyms:1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

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Chemical Property of 1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

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Technology Process of 1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

There total 13 articles about 1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.6%

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1033766-31-2
1-cyclohexylamino-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

: 1033766-32-3
1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

Reference yield:

: 96-72-0
2-chloro-5-nitrobenzenesulfonamide

: 1033766-32-3
1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; ammonium carbonate / copper(II) sulfide / water / 4 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 26 h / 25 °C / 760.05 Torr

3.1: pyridine / acetonitrile / 16 h / 25 °C

4.1: diethyl ether; N,N-dimethyl acetamide / 1 h / 25 °C

5.1: sodium hydroxide / water / 1.5 h / 100 °C

5.2: 0 °C / pH 1 - 2

6.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; ammonia; hydrogen; ammonium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; copper(II) sulfide; In tetrahydrofuran; diethyl ether; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 852547-04-7
benzyl 2-azabicyclo[3.3.0]octane-3-carboxylate

: 1033766-32-3
1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethanol / 4 h / 25 °C

2: methanol / hexane; benzene / 1 h / 0 - 25 °C

3: toluene / 4 h / 80 °C

4: cyclohexanone; sodium cyanoborohydride / acetic acid / 16 h / 25 °C

5: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

With 4-methyl-morpholine; methanol; hydrogen; cyclohexanone; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium 10% on activated carbon; In methanol; ethanol; hexane; acetic acid; N,N-dimethyl-formamide; toluene; benzene;