2-AZABICYCLO[3,3,1] OCTANYL-3-FORMIC ACID

Base Information

• Chemical Name: 2-AZABICYCLO[3,3,1] OCTANYL-3-FORMIC ACID
• CAS No.: 118353-96-1
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.197
• Mol file: 118353-96-1.mol

Synonyms:Octahydrocyclopenta[b]pyrrole-2-carboxylicacid

Chemical Property of 2-AZABICYCLO[3,3,1] OCTANYL-3-FORMIC ACID

Chemical Property:

• Boiling Point: 304.3°Cat760mmHg
• PKA: 2.47±0.20(Predicted)
• Flash Point: 137.9°C
• PSA: 49.33000
• Density: 1.182g/cm³
• LogP: 1.32050

Purity/Quality:

98%min ^*data from raw suppliers

2-Azabicyclo[3.3.0]Octanyl-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AZABICYCLO[3,3,1] OCTANYL-3-FORMIC ACID

There total 5 articles about 2-AZABICYCLO[3,3,1] OCTANYL-3-FORMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(2R,3aS,6aR)-1-Acetyl-octahydro-cyclopenta[b]pyrrole-2-carbonitrile (87623-98-1,88585-95-9,89299-92-3,89299-93-4,110549-38-7,110549-39-8) → (2S,3aR,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid (87679-21-8,87679-60-5,88547-76-6,88547-86-8,93381-12-5,96844-79-0,105307-53-7,109428-53-7,118353-96-1,121154-36-7,128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/S0040-4039(00)87864-8

Reference yield:

N-[(1S,2R)-2-(2-Chloro-2-cyano-ethyl)-cyclopentyl]-acetamide (89226-36-8) → (2S,3aR,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid (87679-21-8,87679-60-5,88547-76-6,88547-86-8,93381-12-5,96844-79-0,105307-53-7,109428-53-7,118353-96-1,121154-36-7,128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 0 °C

2: 74 percent / 5N HCl / Heating

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)87864-8

Reference yield:

cyclopentene (142-29-0) → (2S,3aR,6aS)-Octahydro-cyclopenta[b]pyrrole-2-carboxylic acid (87679-21-8,87679-60-5,88547-76-6,88547-86-8,93381-12-5,96844-79-0,105307-53-7,109428-53-7,118353-96-1,121154-36-7,128900-19-6,411232-21-8,726691-28-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) mercuric nitrate, sodium chloride 2.) sodium borohydride / 2.) ethanol, from-15 deg C to 15 deg C

2: NaH / dimethylformamide / 0 °C

3: 74 percent / 5N HCl / Heating

With hydrogenchloride; sodium tetrahydroborate; sodium hydride; mercury(II) nitrate; sodium chloride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)87864-8

upstream raw materials:

(2R,3aS,6aR)-1-Acetyl-octahydro-cyclopenta[b]pyrrole-2-carbonitrile

N-[(1S,2R)-2-(2-Chloro-2-cyano-ethyl)-cyclopentyl]-acetamide

cyclopentene

(3aR,6aR)-octahydrocyclopentapyrrole

Downstream raw materials:

benzyl (1R^*,3R^*,5R^*)-2-azabicyclo<3.3.0>octane-3-carboxylate

octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

1-{cyclohexyl-[2-(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)acetyl]amino}octahydro-cyclopenta[b]pyrrole-2-carboxylic acid methyl ester

N-[3-(4-cyclohexyl-7-hydroxy-5-oxo-2,3,3a,4,5,7a,8,8a-octahydro-1H-3b,4-diaza-cyclopenta[a]inden-6-yl)-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl]methanesulfonamide

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