5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

Base Information

Chemical Name:5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol
CAS No.:1093944-34-3
Molecular Formula:C₁₉H₂₁NO₃S
Molecular Weight:343.447
Hs Code.:

Synonyms:5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

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Technology Process of 5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

There total 8 articles about 5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1093944-24-1
N-[cyclopropyl(5-methylfuran-2-yl)methyl]-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

: 1093944-34-3
5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

Guidance literature:: With gold(III) chloride; In [D₃]acetonitrile; at 20 ℃; for 0.05h;
DOI:10.1002/ejoc.200800656

Reference yield: 35.0%

: 1093944-24-1
N-[cyclopropyl(5-methylfuran-2-yl)methyl]-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

: 1093944-34-3
5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

: 1403650-91-8
2-cyclopropyl-4-(5-methylfuran-2-yl)-1-tosyl-2,5-dihydro-1H-pyrrole

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In dichloromethane; at 20 ℃; for 0.05h;
DOI:10.1002/chem.201200306

Reference yield:

: 463352-90-1
4-methyl-N-[(5-methylfuran-2-yl)methylene]benzenesulfonamide

: 1093944-34-3
5-methyl-2-[(4-methylphenyl)sulfonyl]-1-cyclopropyl-2,3-dihydro-1H-isoindol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -47 - 20 °C / Inert atmosphere

2: potassium carbonate / acetone; toluene / 24 h / 20 °C

3: gold(III) chloride / dichloromethane; acetonitrile / 0.17 h / 20 °C / Inert atmosphere

With gold(III) chloride; potassium carbonate; In tetrahydrofuran; dichloromethane; acetone; toluene; acetonitrile;
DOI:10.1002/chem.201200091