(R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide
• CAS No.: 796966-21-7
• Molecular Formula: C₂₀H₁₈ClNO₂S
• Molecular Weight: 371.887
• Mol file: 796966-21-7.mol

Synonyms:(R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Chemical Property of (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide

There total 21 articles about (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triphenylboroxine (3262-89-3) + N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide (357417-22-2) → (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (796966-21-7) + (S)-N-((4-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (796966-17-1)

Guidance literature:

With di-μ-chloro-bis[(η⁵-(4`R,5`R)-(Sp)-2-(2`-4`,5`-dihydro-4`,5`-diphenyl-1`-tosyl-1`H-imidazolyl)cyclopentadienyl,1-C,3`-N)(η⁵-cyclopentadienyl)-iron(II)]dipalladium(II); silver(I) acetate; In chlorobenzene; at 65 ℃; for 20h; Inert atmosphere;

DOI:10.1002/chem.201605244

Reference yield: 99.0%

triphenylboroxine (3262-89-3) + N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide (357417-22-2) → (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (796966-21-7)

Guidance literature:

With di-μ-chlorobis[η⁵-(4'R,5'R)-(S_p)-2-(2'-4',5'-dihydro-4',5'-diphenyl-1'-tosyl-1'H-imidazolyl)cyclopentadienyl, (1-C,3'-N)(η⁵-cyclopentadienyl)-iron(II)]dipalladium(II); silver(I) acetate; In chlorobenzene; acetonitrile; at 65 ℃; for 20h; Reagent/catalyst; Temperature; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201501846

Reference yield: 98.0%

triphenylboroxine (3262-89-3) + N-(p-chlorobenzylidene)-p-toluenesulfonamide (3157-65-1) → (R)-N-((p-chlorophenyl)(phenyl)methyl)-4-methylbenzenesulfonamide (796966-21-7)

Guidance literature:

With chlorobis(ethylene)rhodium(I) dimer; (S)-(+)-[η⁶-1-bis(3,5-dimethylphenyl)phosphino-2-(3-diphenylphosphino-2-methylpropenyl)benzene-P]chromium(0) dicarbonyl; potassium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 12h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/ja503060e

upstream raw materials:

N-(4-chlorobenzylidene)-4-methylbenzenesulfonamide

phenylboronic acid

N-(p-chlorobenzylidene)-p-toluenesulfonamide

N-(benzylidene)-p-methylbenzenesulfonamide