3157-65-1

Upstream product

• 10504-98-0 N-(4-chlorobenzyl)-p-toluenesulfonamide 
• 104-88-1 4-chlorobenzaldehyde 
• 4083-64-1 Tosyl isocyanate 
• 70-55-3 toluene-4-sulfonamide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 127-65-1 chloroamine-T 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 1058-14-6 N-p-tolylsulfonylphosphine imide 
• 2403-61-4 p-chlorobenzaldehyde diethyl acetal 
• 69900-95-4 2-(p-toluenesulfonyl)-3-(p-chlorophenyl)oxaziridine 
• 101359-08-4 N-tosyltriphenylbismuthimine 
• 941-55-9 4-toluenesulfonyl azide 

Downstream Products

• 53235-79-3 (E)-diethyl 1-ethoxycarbonyl-2-(4-chlorophenyl)-vinylphosphonate 
• 861908-93-2 methyl 2-diazo-3-(p-chloro)phenyl-3-[(N-tosyl)amino]propanoate 

Relevant academic research and scientific papers

Copper(II) triflate-catalyzed and tosyl isocyanate-mediated three-step tandem synthesis of 9-arylfluorenes

A Cu(OTf)2-catalyzed and TsNCO-mediated three-step tandem synthesis of 9-arylfluorenes were developed from biphenyls and aryl aldehydes, by which the electron-poor 9-aryl substituted fluorenes were synthesized smoothly. Its success is mainly at

Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity

A Y(OTf)3-catalyzed [3+2] cycloaddition of 1,3,5-triazinanes with donor-acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an SN1-like pathway. Furthermore, these imidazolidines exhibit promising anti-tumor activity against a series of human cancer cell lines. (Figure presented.).

Facile synthesis, antimicrobial and antiviral evaluation of novel substituted phenyl 1,3-thiazolidin-4-one sulfonyl derivatives

A series of novel substituted phenyl 1, 3-thiazolidin-4-one sulfonyl derivatives 5 (a-t) were synthesized and screened for their in-vitro anti-microbial and anti-viral activity. The result of the anti-microbial assay demonstrated compounds 5d, 5f, 5g, 5h,

Chiral-Directing-Group-Assisted Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C?H Bond to Aldimines with Subsequent Intramolecular Cyclization

By using a chiral directing group, an asymmetric rhodium(III)-catalyzed C?H bond addition to aldimines followed by intramolecular cyclization to form chiral isoindolinones has been achieved (up to 68 % yield, up to 93 % ee). A three-component variant that resembles Mannich reaction was also realized (41 % yield, 83 % ee). Product elaborations and preliminary mechanistic studies were described.

Reductive alkylation of imines via asymmetric Cu-catalyzed addition of organozirconium reagents

Chiral amines are important as medicines or agrochemicals. They are often assembled by nucleophilic addition to corresponding compounds featuring C[dbnd]N bond. Pre-made organometallics are typical nucleophiles in this reaction. In this work, we describe

Pyridinyl Amide Ion Pairs as Lewis Base Organocatalysts

Pyridinyl amide ion pairs carrying various electron-withdrawing substituents were synthesized with selected ammonium or phosphonium counterions. Compared to neutral pyridine-based organocatalysts, these new ion pair Lewis bases display superior catalytic

TfOH-catalyzed formal [3+2] cycloaddition of N-tosylaziridine dicarboxylates and nitriles: Synthesis of tetrafunctionalized 2-imidazolines

We developed an efficient method for synthesis of tetrafunctionalized 2-imidazolines using TfOH-catalyzed formal [3+2] cycloaddition of N-tosylaziridine dicarboxylates and nitriles. This is the first report of C–N bond cleavage of N-tosylaziridine dicarboxylates catalyzed by Br?nsted acid and the reaction worked well over wide scope of substrates in good to excellent yields under mild conditions. The method has the potential to be applied to pharmaceutical design and synthesis of tetrafunctionalized 2-imidazolines.

Iron-based nanomaterials used as magnetic mesoporous nanocomposites to catalyze the preparation of N-sulfonylimines

A new magnetic nanocatalyzed synthetic method for the synthesis of aldimines was evidenced. The reaction was carried out in a Schlenk tube under reflux conditions using various solvents and different nanomaterials as catalysts. In these reactions, an exce

Silica-supported zinc chloride (ZnCl2/SiO2)-induced efficient protocol for the synthesis of N-sulfonyl imines and 2-Arylbenzothiazole

A straightforward strategy for the synthesis of N-sulfonyl imine derivatives from sulfonamides and aryl aldehydes utilizing Silica-supported zinc chloride (ZnCl2/SiO2, silzic) as a catalyst under solvent-free conditions has been developed. 2-Arylbenzothiazole derivatives were also synthesized by the reaction of 2-aminothiophenol with aryl aldehydes under the same conditions. This procedure has advantages of high yields, mild reaction condition, simple procedure, low cost, and simplicity of workup. The catalyst has the same efficiency on its reuse up to three times.

Photoredox Radical/Polar Crossover Enables Construction of Saturated Nitrogen Heterocycles

Photoredox-mediated radical/polar crossover (RPC) processes offer new avenues for the synthesis of cyclic molecules. This process has been realized for the construction of medium-sized saturated nitrogen heterocycles. Photocatalytically generated alkyl ra