3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

Base Information

Chemical Name:3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine
CAS No.:1262630-05-6
Molecular Formula:C₂₀H₁₆F₃N₅
Molecular Weight:392.304
Hs Code.:

Synonyms:3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

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Chemical Property of 3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

Chemical Property:

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Technology Process of 3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

There total 4 articles about 3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 425379-31-3
2-(5-bromo-2-fluorophenyl)-3,5-difluoropyridine

: 1262630-50-1
3-(tert-butyl-d9)imidazo[1,2-b][1,2,4]triazine hydrochloride

: 1262630-05-6
3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

Guidance literature:: With potassium acetate; triphenylphosphine; palladium diacetate; In N,N-dimethyl acetamide; at 130 ℃; for 2h;

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1262630-05-6
3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C

2: trifluoroacetic acid; N-Bromosuccinimide / 40 - 45 °C

3: triphenylphosphine; potassium acetate / palladium diacetate / N,N-dimethyl acetamide / 2 h / 130 °C

With N-Bromosuccinimide; potassium acetate; sodium hydrogencarbonate; triphenylphosphine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In 1,4-dioxane; N,N-dimethyl acetamide; water;

Reference yield:

: 884863-46-1
3,5-difluoro-2-(2-fluorophenyl)pyridine

: 1262630-05-6
3-(tert-butyl-d9)-7-(3-(3,5-difluoropyridin-2-yl)-4-fluorophenyl)imidazo[1,2-b][1,2,4]triazine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; N-Bromosuccinimide / 40 - 45 °C

2: triphenylphosphine; potassium acetate / palladium diacetate / N,N-dimethyl acetamide / 2 h / 130 °C

With N-Bromosuccinimide; potassium acetate; triphenylphosphine; trifluoroacetic acid; palladium diacetate; In N,N-dimethyl acetamide;