425379-31-3Relevant academic research and scientific papers
SUBSTITUTED IMIDAZOTRIAZINES
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Page/Page column 39, (2011/02/24)
This invention relates to novel substituted imidazotriazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases
A pyridazine series of α2/α3 subtype selective GABAA agonists for the treatment of anxiety
Lewis, Richard T.,Blackaby, Wesley P.,Blackburn, Timothy,Jennings, Andrew S. R.,Pike, Andrew,Wilson, Rowan A.,Hallett, David J.,Cook, Susan M.,Ferris, Pushpinder,Marshall, George R.,Reynolds, David S.,Sheppard, Wayne F. A.,Smith, Alison J.,Sohal, Bindi,Stanley, Joanna,Tye, Spencer J.,Wafford, Keith A.,Atack, John R.
, p. 2600 - 2610 (2007/10/03)
The development of a series of GABAA α2/α3 subtype selective pyridazine based benzodiazepine site agonists as anxiolytic agents with reduced sedative/ataxic potential is described, including the discovery of 16, a remarkably α3-selective compou
IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
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Page 54-55, (2010/02/04)
A class of 8-fluoro-3-phenylimidazo[1,2-a]pyridine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group, or by a pyrrolidinonyl group, which is directly attached or bridged by an oxygen atom or by a -NH- or -OCH2- linkage, being selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 and/or α5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
