6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide

Base Information

• Chemical Name: 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide
• CAS No.: 933466-82-1
• Molecular Formula: C₁₄H₉Cl₂N₃O₃S₂
• Molecular Weight: 402.282
• Mol file: 933466-82-1.mol

Synonyms:6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide

Chemical Property of 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide

There total 2 articles about 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-chloro-3-(4-chloroanilino)-1,1-dioxo-1,4,2-benzodithiazine-7-carbonyl chloride (933466-73-0) → 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide (933466-82-1)

Guidance literature:

With ammonia; In water; benzene; at 20 ℃; for 10h;

DOI:10.1016/j.bmc.2007.01.052

Reference yield:

6-chloro-3-(4-chloro-phenylamino)-1,1-dioxo-1H-1λ6-benzo[1,4,2]dithiazine-7-carboxylic acid → 6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide (933466-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / thionyl chloride / benzene / 16 h / Heating

2: 97 percent / ammonia / benzene; H₂O / 10 h / 20 °C

With thionyl chloride; ammonia; In water; benzene;

DOI:10.1016/j.bmc.2007.01.052

Reference yield: 96.0%

6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carboxamide (933466-82-1) + isatoic anhydride (118-48-9) → 6'-chloro-5-(4-chlorophenyl)-1',1',2,6-tetraoxo-1,2,5,6-tetrahydrospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-7'-carboxamide (1450743-37-9)

Guidance literature:

In toluene; at 20 ℃; for 44h; Reflux;

DOI:10.1007/s00706-013-1010-y

upstream raw materials:

6-chloro-3-(4-chloroanilino)-1,1-dioxo-1,4,2-benzodithiazine-7-carbonyl chloride

Downstream raw materials:

6-chloro-3-(4-chlorophenylamino)-1,1-dioxo-1,4,2-benzodithiazine-7-carbonitrile

6'-chloro-5-(4-chlorophenyl)-1',1',2,6-tetraoxo-1,2,5,6-tetrahydrospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-7'-carboxamide