N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

Base Information

Chemical Name:N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide
CAS No.:149859-26-7
Molecular Formula:C₃₅H₄₃N₃O₇
Molecular Weight:617.742
Hs Code.:

N-<(1R-(1α,2β,3α))-1-<N'-<O-(p-methoxybenzyl)>-N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

Synonyms:N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

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Chemical Property of N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

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Technology Process of N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

There total 15 articles about N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 96136-31-1
(S)-2-amino-3-(4-methoxyphenyl)-N-methylpropionamide

: 149891-77-0
<1R-(1α,2β,3α)>-1--N-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)cyclopropane-2-carboxylic acid

: 149859-26-7
N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 82290-65-1
(Z)-4-methylpent-2-en-1-ol

: 149859-26-7
N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 7 steps

1: 76 percent / N,N-dimethylaniline, Et₃N / CH₂Cl₂ / 1) 0 deg C, 15 min, 2) r.t., 30 min

2: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

3: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 4 h

4: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

5: K₂CO₃ / methanol / 12 h / Ambient temperature

6: 85 percent / 8 N Jones reagent / acetone / 2 h / 0 - 5 °C

7: 74 percent / 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

With jones reagent; trimethylaluminum; potassium carbonate; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)90212-1

Reference yield:

: 149859-29-0
4-methyl-2(Z)-pentenyl diazoacetate

: 149859-26-7
N-<(1R-(1α,2β,3α))-1--N'-(p-methoxybenzyl)hydroxycarboxamido>-3-(2-propyl)-2-cyclopropanoyl>-O-methyl-L-tyrosine-N-methylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / Rh₂<-CH₂-CH₂-CH(CO₂Me)-N=CO->4 / CH₂Cl₂ / Heating

2: 1) Me₃Al / 1) hexane, ClCH₂CH₂Cl, r.t., 1 h, 2) ClCH₂CH₂Cl, 83 deg C, 4 h

3: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / methanol / 12 h / Ambient temperature

5: 85 percent / 8 N Jones reagent / acetone / 2 h / 0 - 5 °C

6: 74 percent / 1-hydroxybenzotriazole, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 24 h / Ambient temperature

With jones reagent; trimethylaluminum; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridinium chlorochromate; Rh2<-CH2-CH2-CH(CO2Me)-N=CO->4; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)90212-1