(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

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Chemical Name:(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol
CAS No.:612065-40-4
Molecular Formula:C₂₃H₃₀O₂S
Molecular Weight:370.556
Hs Code.:

Synonyms:(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

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Technology Process of (αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

There total 7 articles about (αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 75-11-6
diiodomethane

: 100-52-7
benzaldehyde

: EtCu*MgBr₂

: 61783-64-0
(+)-(S)-1-hexynyl p-tolyl sulfoxide

: 612065-40-4
(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

Guidance literature:: EtCu*MgBr₂; (+)-(S)-1-hexynyl p-tolyl sulfoxide; In tetrahydrofuran; at -20 ℃;

diiodomethane; benzaldehyde; With diethylzinc; In tetrahydrofuran; at -20 ℃; for 2h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/chem.200800580

Reference yield: 78.0%

: 75-11-6
diiodomethane

: 100-52-7
benzaldehyde

: 61783-64-0
(+)-(S)-1-hexynyl p-tolyl sulfoxide

: 612065-40-4
(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

Guidance literature:: ethylmagnesium halide; With copper(l) iodide; In tetrahydrofuran; at -30 ℃; for 0.75h;

(+)-(S)-1-hexynyl p-tolyl sulfoxide; In tetrahydrofuran; at -30 ℃;

diiodomethane; benzaldehyde; With diethylzinc; In tetrahydrofuran; hexane; at -30 ℃;
DOI:10.1021/ja060498q

Reference yield: 78.0%

: 14399-53-2
bis(iodomethyl)zinc

: 100-52-7
benzaldehyde

: 61783-64-0
(+)-(S)-1-hexynyl p-tolyl sulfoxide

: 612065-40-4
(αR)-α-[(1R)-1-ethyl-1-[1-[(S)-(4-methylphenyl)sulfinyl]ethenyl]pentyl]-benzenemethanol

Guidance literature:: (+)-(S)-1-hexynyl p-tolyl sulfoxide; EtCuMgBr₂; In tetrahydrofuran; at -70 - -30 ℃;

benzaldehyde; In tetrahydrofuran; at -30 - -15 ℃; for 0.25h;

bis(iodomethyl)zinc; In tetrahydrofuran; at -15 ℃; for 0.0833333h;
DOI:10.1021/ja036872t