1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one

Base Information

Chemical Name:1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one
CAS No.:176694-81-8
Molecular Formula:C₁₃H₁₇NO₂
Molecular Weight:219.283
Hs Code.:
DSSTox Substance ID:DTXSID301245353
Nikkaji Number:J1.736.854K

Synonyms:DTXSID301245353;1-[(1S)-2-Hydroxy-1-phenylethyl]-2-piperidinone;1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one;176694-81-8

Suppliers and Price of 1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:219.125928785
Heavy Atom Count:16
Complexity:236

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(C(=O)C1)C(CO)C2=CC=CC=C2
Isomeric SMILES:C1CCN(C(=O)C1)[C@H](CO)C2=CC=CC=C2

Technology Process of 1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one

There total 6 articles about 1-[(S)-2-Hydroxy-1-phenylethyl]piperidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 176778-23-7
(3S,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 176694-81-8
1-((S)-2-Hydroxy-1-phenyl-ethyl)-piperidin-2-one

Guidance literature:: With triethylsilane; titanium tetrachloride; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1080/00397919608003529

Reference yield:

: 1093134-17-8
C₁₉H₃₁NO₂Si

: 176694-81-8
1-((S)-2-Hydroxy-1-phenyl-ethyl)-piperidin-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h;

Reference yield:

: 6591-61-3,24461-61-8,26682-99-5,37760-98-8
(S)-Phenylglycine methyl ester

: 176694-81-8
1-((S)-2-Hydroxy-1-phenyl-ethyl)-piperidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) acetyl chloride / 1.) 6 h, reflux, CH₂Cl₂ 2) reflux, 24 h, CH₂Cl₂

2: 1.) sodium borohydride, 2.) HCl / 1.) -15 deg C, MeOH, 2.) 3 h, r.t., pH 1, MeOH

3: 84 percent / Et₃SiH, TiCl₄ / CH₂Cl₂ / 16 h / Ambient temperature

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; titanium tetrachloride; acetyl chloride; In dichloromethane;
DOI:10.1080/00397919608003529