1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

Base Information

Chemical Name:1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone
CAS No.:1415822-43-3
Molecular Formula:C₂₅H₂₅N₅O₂
Molecular Weight:427.506
Hs Code.:

Synonyms:1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

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Chemical Property of 1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

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Technology Process of 1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

There total 3 articles about 1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415824-74-6
N-(2-aza-spiro[3.3]hept-6-yl)-5-(4-phenoxy-phenyl)-pyrimidine-4,6-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1415822-43-3
1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 12h;
DOI:10.1021/acs.jmedchem.9b00794

Reference yield:

: 1211586-09-2
6-amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester

: 1415822-43-3
1-{6-[6-amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino]-2-aza-spiro[3.3]hept-2-yl}-propenone

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 3 h / 160 °C

2: potassium carbonate; palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 3 h / 150 °C

3: methanol; hydrogenchloride / diethyl ether / 12 h / 20 °C

4: sodium hydrogencarbonate / water; tetrahydrofuran / 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; methanol; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diethyl ether; water; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.9b00794