(S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol

Base Information

• Chemical Name: (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol
• CAS No.: 204253-44-1
• Molecular Formula: C₂₇H₃₂O₄
• Molecular Weight: 420.549
• Mol file: 204253-44-1.mol

Synonyms:(S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol

Chemical Property of (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol

There total 4 articles about (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-hydroxyl-3,3-dimethylbutyric acid (13748-90-8,498-36-2) → (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol (204253-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: Et₂NH / CH₂Cl₂

With lithium aluminium tetrahydride; diethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0960-894X(98)00064-X

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol (204253-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / triethylamine; CH₂Cl₂ / Ambient temperature

2: Li₂CuCl₄ / tetrahydrofuran

With dilithium tetrachlorocuprate; In tetrahydrofuran; dichloromethane; triethylamine;

DOI:10.1016/0040-4039(96)00745-9

Reference yield:

isopropylmagnesium chloride (1068-55-9) + (S)-glycidyl 4,4’-dimethoxytrityl ether (834906-31-9) → (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol (204253-44-1)

Guidance literature:

With dilithium tetrachlorocuprate; In tetrahydrofuran;

DOI:10.1016/0040-4039(96)00745-9

upstream raw materials:

isopropylmagnesium chloride

(S)-glycidyl 4,4’-dimethoxytrityl ether

(S)-(-)-4-methyl-1,2-pentanediol

4,4'-dimethoxytrityl chloride

Downstream raw materials:

(S)-(-)-4-methyl-1,2-pentanediol