834906-31-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 57044-25-4 (R)-oxiranemethanol 

Downstream Products

• 204253-44-1 (S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-methyl-pentan-2-ol 
• 834906-32-0 1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol 
• 168332-12-5 (S)-1-<3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl>thymine 
• 851050-21-0 (S)-9-(3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl)adenine 
• 127757-40-8 (S)-1-(3-(4,4′-dimethoxytrityloxy)-2-hydroxypropyl)-N4-benzoylcytosine 
• 494784-12-2 (S)-1-[3-(4,4'-dimethoxytrityloxy)-2-hydroxypropyl]uracil 
• 115196-70-8 3'-O-Bis(p-methoxyphenyl)phenylmethyl-9-(S)-(2,3-dihydroxypropyl)-N⁶-benzoyladenine 
• 916599-39-8 Acetic acid (S)-1-(6-amino-purin-9-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester 
• 916599-36-5 acetic acid 1-(4-benzoylamino-2-oxo-2H-pyrimidin-1-ylmethyl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl ester 
• 916599-40-1 Acetic acid (S)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-1-(6-dibenzoylamino-purin-9-ylmethyl)-ethyl ester 

Relevant academic research and scientific papers

TRANSLOCATION CONTROL ELEMENTS, REPORTER CODES, AND FURTHER MEANS FOR TRANSLOCATION CONTROL FOR USE IN NANOPORE SEQUENCING

Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocati

P-Stereodefined phosphorothioate analogs of glycol nucleic acids—synthesis and structural properties

Enantiomerically pure, protected acyclic nucleosides of the GNA type (glycol nucleic acids) (GN′), obtained from (R)-(+)- and (S)-(?)-glycidols and the four canonical DNA nucleobases (Ade, Cyt, Gua and Thy), were transformed into 3′-O-DMT-prote

Solid phase synthesis is solid including the fluorine reagent and its application

The present invention provides a fluorine-containing solid-phase synthesis reagent and an application thereof. Specifically the present invention provides a fluorine-containing compound capable of being adopted as a nucleic acid monomer, wherein the compo

OLIGONUCLEOTIDE-LIGAND CONJUGATES AND PROCESS FOR THEIR PREPARATION

The present invention relates to ligand conjugates of oligonucleotides (e.g., iRNA agents) and methods for their preparation. The ligands are derived primarily from monosaccharides These conjugates are useful for the in vivo delivery of oligonucleotides.

Synthesis of glycol nucleic acids

Starting from glycidol, the synthesis of dimethoxytritylated glycol nucleoside phosphoramidites of adenine (A), thymine (T), uracil (U), guanine (G), and cytosine (C) is reported. These phosphoramidites are the building blocks for the automated solid phas

Glycerol nucleoside triphosphates: Synthesis and polymerase substrate activities

The synthesis of (S)-glycerol nucleoside triphosphates (gNTPs) and the analysis of their substrate activities for enzymatic polymerization is described. NTPs with simplified carbohydrate backbones such as the tNTPs (α-L-threose-NTPs) are polymerase substr

Synthesis of propane-2,3-diol combinatorial monomers

Base catalyzed reaction of heterocyclic bases with R-(+)-glycidol gives heteroaryl-propane-2,3-diols which are functionalized to the 3-O-dimethoxytrityl-2-O-phosphoramidites. A dimethoxytrityl-glycidol is reacted with alkyl or aryl Grignard reagents and then phosphitylated to yield 1-O-dimethoxytrityl-2-phosphoramidites. These compounds can be used for combinatorial oligomer synthesis.