(2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine

Base Information

• Chemical Name: (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine
• CAS No.: 100008-94-4
• Molecular Formula: C₁₈H₁₅N₃O₃
• Molecular Weight: 321.335
• Mol file: 100008-94-4.mol

Synonyms:(2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine

Chemical Property of (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine

There total 3 articles about (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

6-(2-hydroxyphenyl)-4-methyl-5-nitro-2-phenylpyrimidine (100008-91-1) + methyl iodide (74-88-4) → (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine (100008-94-4)

Guidance literature:

With potassium hydroxide; In methanol; 1.) 1 h, reflux; 2.) 3 h, reflux;

DOI:10.1248/cpb.33.2129

Reference yield:

2-methyl-3-nitrochromen-4-one (59507-95-8) → (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine (100008-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.5 percent / NaOEt / ethanol / 1.) 5 min, RT; 2.) 10 min, reflux

2: 75 percent / KOH / methanol / 1.) 1 h, reflux; 2.) 3 h, reflux

With potassium hydroxide; sodium ethanolate; In methanol; ethanol;

DOI:10.1248/cpb.33.2129

Reference yield:

benzamidine monohydrochloride (1670-14-0) → (2-methoxyphenyl)-4-methyl-5-nitro-2-phenylpyridine (100008-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.5 percent / NaOEt / ethanol / 1.) 5 min, RT; 2.) 10 min, reflux

2: 75 percent / KOH / methanol / 1.) 1 h, reflux; 2.) 3 h, reflux

With potassium hydroxide; sodium ethanolate; In methanol; ethanol;

DOI:10.1248/cpb.33.2129

upstream raw materials:

6-(2-hydroxyphenyl)-4-methyl-5-nitro-2-phenylpyrimidine

methyl iodide

2-methyl-3-nitrochromen-4-one

benzamidine monohydrochloride

Refernces