diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester

Base Information

• Chemical Name: diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester
• CAS No.: 1313715-47-7
• Molecular Formula: C₄₄H₅₁N₂O₇P
• Molecular Weight: 750.872
• Mol file: 1313715-47-7.mol

Synonyms:diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester

Chemical Property of diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester

There total 6 articles about diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(S)-1-[bis(4-methoxyphenyl)(phenyl)methoxy]-3-[4-(furan-2-yl)benzyloxy]propan-2-ol (1313715-45-5) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester (1313715-47-7)

Guidance literature:

(S)-1-[bis(4-methoxyphenyl)(phenyl)methoxy]-3-[4-(furan-2-yl)benzyloxy]propan-2-ol; With N,N-diisopropylamine tetrazolide; In butan-1-ol; at 20 ℃; Inert atmosphere;

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1002/chem.201100067

Reference yield: 79.0%

(S)-1-[bis(4-methoxyphenyl)(phenyl)methoxy]-3-[4-(furan-2-yl)benzyloxy]propan-2-ol (1313715-45-5) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester (1313715-47-7)

Guidance literature:

With N,N-diisopropylammonium tetrazolide; In dichloromethane; at 0 ℃; for 48h;

DOI:10.1002/cbic.201402602

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → diisopropylamidophosphorous acid (S)-2-[bis(4-methoxyphenyl)(phenyl)methoxy]-1-[4-(furan-2-yl)benzyloxymethyl]ethyl ester 2-cyanoethyl ester (1313715-47-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / toluene / 20 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.58 h / -78 - 0 °C / Inert atmosphere

2.2: 1.5 h / 0 °C / Inert atmosphere

2.3: 20 - 50 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 2 h / Cooling with ice

4.1: pyridine / 2 h / 0 °C / Inert atmosphere

5.1: N,N-diisopropylamine tetrazolide / butan-1-ol / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; n-butyllithium; N,N-diisopropylamine tetrazolide; potassium hydroxide; In tetrahydrofuran; pyridine; hexane; water; toluene; butan-1-ol;

DOI:10.1002/chem.201100067

upstream raw materials:

(S)-1-[bis(4-methoxyphenyl)(phenyl)methoxy]-3-[4-(furan-2-yl)benzyloxy]propan-2-ol

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

(S)-4-[4-(furan-2-yl)benzyloxymethyl]-2,2-dimethyl-1,3-dioxolane

(R)-3-[4-(furan-2-yl)benzyloxy]propane-1,2-diol