acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Base Information

Chemical Name:acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester
CAS No.:745809-56-7
Molecular Formula:C₃₂H₄₄O₉Si
Molecular Weight:600.781
Hs Code.:

acetic acid 3-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Synonyms:acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

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Chemical Property of acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

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Technology Process of acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

There total 10 articles about acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 745809-29-4
(+)-3-(tert-butyldimethylsilyloxy)-4-(3-acetoxy-5-methylphenyl)-1-butyne

: 745809-56-7
acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: (+)-3-(tert-butyldimethylsilyloxy)-4-(3-acetoxy-5-methylphenyl)-1-butyne; pentacarbonyl[1-[2,5-bis(methoxymethoxy)phenyl]-1-methoxymethylidene]chromium; In n-heptane; at 57 ℃; for 14h;

With air; In n-heptane; ethyl acetate; for 0.25h;
DOI:10.1021/jo049426c

Reference yield:

: 34946-83-3
2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone

: 745809-56-7
acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 57 percent / sulfuric acid / 16 h

2.1: 2,6-lutidine

3.1: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

4.1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / -78 - 0 °C

5.1: triphenylphosphine / CH₂Cl₂ / 0.08 h

6.1: 0.37 g / n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

7.1: 99 percent / TBAF; acetic acid / tetrahydrofuran / 2 h

8.1: 98 percent / pyridine / 18 h / 23 °C

9.1: heptane / 14 h / 57 °C

9.2: 35 percent / air / heptane; ethyl acetate / 0.25 h

With pyridine; 2,6-dimethylpyridine; n-butyllithium; oxalyl dichloride; sulfuric acid; tetrabutyl ammonium fluoride; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; n-heptane; dichloromethane; water; 5.1: Swern oxidation / 10.1: Doetz benzannulation;
DOI:10.1021/jo049426c

Reference yield:

: 108-39-4
3-methyl-phenol

: 745809-56-7
acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 52 percent / Br₂ / acetic acid

2.1: 57 percent / sulfuric acid / 16 h

3.1: 2,6-lutidine

4.1: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

5.1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / -78 - 0 °C

6.1: triphenylphosphine / CH₂Cl₂ / 0.08 h

7.1: 0.37 g / n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

8.1: 99 percent / TBAF; acetic acid / tetrahydrofuran / 2 h

9.1: 98 percent / pyridine / 18 h / 23 °C

10.1: heptane / 14 h / 57 °C

10.2: 35 percent / air / heptane; ethyl acetate / 0.25 h

With pyridine; 2,6-dimethylpyridine; n-butyllithium; oxalyl dichloride; sulfuric acid; tetrabutyl ammonium fluoride; bromine; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; n-heptane; dichloromethane; water; acetic acid; 6.1: Swern oxidation / 11.1: Doetz benzannulation;
DOI:10.1021/jo049426c