Technology Process of A-71623
There total 11 articles about A-71623 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
under 3040 Torr;
Yield given;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 49 percent / NMM, benzotriazol-1-yltris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide / Ambient temperature
2: 50percent diethylamine / acetonitrile / 0.67 h
3: DIEA, 1-hydroxybenzotriazole hydrate, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature
4: TFA / CH2Cl2 / 1 h / Ambient temperature
5: DIEA / CH2Cl2 / Ambient temperature
6: H2 / 10percent Pd/C / methanol / 3040 Torr
With
4-methyl-morpholine; (benzotriazol-1-yloxyl)tris(dimethylamino)phosphonium hexafluorophosphate; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.2 g / 2N NaOH / H2O; dioxane / 0 - 20 °C
2: EDC / CH2Cl2 / 1 h
3: DIEA, 1-hydroxybenzotriazole hydrate, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature
4: TFA / CH2Cl2 / 1 h / Ambient temperature
5: DIEA / CH2Cl2 / Ambient temperature
6: H2 / 10percent Pd/C / methanol / 3040 Torr
With
sodium hydroxide; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
![(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester](/Databaselist/images/loading.webp)
