(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Chemical Name:(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester
CAS No.:141408-89-1
Molecular Formula:C₅₁H₆₂N₈O₉
Molecular Weight:931.101
Hs Code.:

(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Synonyms:(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Chemical Property of (S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Technology Process of (S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

There total 10 articles about (S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5241-58-7
L-Phenylalanine amide

: 141408-89-1
(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / NMM, benzotriazol-1-yltris(dimethylamino)phosphonium hexafluorophosphate / dimethylformamide / Ambient temperature

2: 50percent diethylamine / acetonitrile / 0.67 h

3: DIEA, 1-hydroxybenzotriazole hydrate, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

4: TFA / CH₂Cl₂ / 1 h / Ambient temperature

5: DIEA / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; (benzotriazol-1-yloxyl)tris(dimethylamino)phosphonium hexafluorophosphate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 13734-28-6
Boc-Lys-OH

: 141408-89-1
(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.2 g / 2N NaOH / H₂O; dioxane / 0 - 20 °C

2: EDC / CH₂Cl₂ / 1 h

3: DIEA, 1-hydroxybenzotriazole hydrate, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

4: TFA / CH₂Cl₂ / 1 h / Ambient temperature

5: DIEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 614-68-6
2-tolyl isocyanate

: 141408-89-1
(S)-3-{[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-6-(3-o-tolyl-ureido)-hexanoyl]-methyl-amino}-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.2 g / 2N NaOH / H₂O; dioxane / 0 - 20 °C

2: EDC / CH₂Cl₂ / 1 h

3: DIEA, 1-hydroxybenzotriazole hydrate, 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature

4: TFA / CH₂Cl₂ / 1 h / Ambient temperature

5: DIEA / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;