2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

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Chemical Name:2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid
CAS No.:1300748-36-0
Molecular Formula:C₂₂H₂₀ClFN₄O₅
Molecular Weight:474.876
Hs Code.:

Synonyms:2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

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Chemical Property of 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

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Technology Process of 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

There total 7 articles about 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300748-35-9
(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

: 1300748-36-0
2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

Guidance literature:: (S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 1300747-64-1
methyl 3-methyl-2-(5-(4-nitrophenyl)oxazole-2-carboxamido)butanoate

: 1300748-36-0
2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

2.1: tetrahydrofuran / 16 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.2: pH 2

With iron; ammonium chloride; lithium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1300748-36-0
2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hexamethylenetetramine / dichloromethane / 1 h / 20 °C

2.1: triethylamine / ethyl acetate

2.2: 2 h / 80 °C

3.1: trichlorophosphate / 6 h / 80 °C

4.1: triethylamine / ethanol / 48 h / 110 °C

5.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

6.1: tetrahydrofuran / 16 h / 20 °C

7.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

7.2: pH 2

With hexamethylenetetramine; iron; ammonium chloride; triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2012.05.016