(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate
CAS No.:1300748-35-9
Molecular Formula:C₂₃H₂₂ClFN₄O₅
Molecular Weight:488.903
Hs Code.:

Synonyms:(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

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Technology Process of (S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

There total 5 articles about (S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300747-63-0
methyl 2-(5-(4-aminophenyl)oxazole-2-carboxamido)-3-methylbutanoate

: 69922-26-5
2-fluoro-4-chlorophenyl isocyanate

: 1300748-35-9
(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 1300747-64-1
methyl 3-methyl-2-(5-(4-nitrophenyl)oxazole-2-carboxamido)butanoate

: 1300748-35-9
(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

2: tetrahydrofuran / 16 h / 20 °C

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2012.05.016

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 1300748-35-9
(S)-methyl 2-(5-(4-(3-(4-chloro-2-fluorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hexamethylenetetramine / dichloromethane / 1 h / 20 °C

2.1: triethylamine / ethyl acetate

2.2: 2 h / 80 °C

3.1: trichlorophosphate / 6 h / 80 °C

4.1: triethylamine / ethanol / 48 h / 110 °C

5.1: iron; ammonium chloride / tetrahydrofuran; ethanol; water / 3 h / 80 °C

6.1: tetrahydrofuran / 16 h / 20 °C

With hexamethylenetetramine; iron; ammonium chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.ejmech.2012.05.016