(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

Base Information

Chemical Name:(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile
CAS No.:887363-23-7
Molecular Formula:C₁₃H₁₄N₂O₄
Molecular Weight:262.265
Hs Code.:

Synonyms:(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

Chemical Property:

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Technology Process of (+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

There total 2 articles about (+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 956428-50-5
(+)-(2R)-[tert-butyl(dimethyl)silyloxy][(2R,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 887363-23-7
(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

Guidance literature:: With hydrogenchloride; In acetonitrile; for 5.5h; Heating;
DOI:10.1021/jo701452a

Reference yield:

: 56522-24-8
tert-butyldimethylsilyl cyanide

: 180062-99-1
3-methoxy-1-(4-methoxy-phenyl)-4-oxo-azetidine-2-carbaldehyde

: 887363-23-7
(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 887363-25-9
(+)-(2S)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 956428-49-2
(+)-(2S)-[tert-butyl(dimethyl)silyloxy][(2R,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 956428-50-5
(+)-(2R)-[tert-butyl(dimethyl)silyloxy][(2R,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

Guidance literature:: With tin(IV) chloride; In acetonitrile; for 5h; Further Variations:; Reagents; Solvents; Temperatures; Product distribution; Heating;
DOI:10.1021/jo701452a

Reference yield:

: 887363-23-7
(+)-(2R)-hydroxy[(2S,3R)-3-methoxy-1-(4-methoxyphenyl)-4-oxoazetidin-2-yl]acetonitrile

: 3966-32-3
(R)-methoxyphenylacetic acid

: C₂₂H₂₂N₂O₆

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/b517917c