5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

Base Information

Chemical Name:5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole
CAS No.:698982-26-2
Molecular Formula:C₂₀H₃₅NO₃SiSn
Molecular Weight:484.298
Hs Code.:

Synonyms:5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

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Chemical Property of 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

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Technology Process of 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

There total 5 articles about 5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 698982-20-6
3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

: 698982-26-2
5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

Guidance literature:: With hexamethyldistannane; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; at 90 ℃; for 3h;

Reference yield:

: 698982-14-8
[3-(4-bromo-2-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methanol

: 698982-26-2
5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: hexamethyldistannane / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 90 °C

With dmap; hexamethyldistannane; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 22532-62-3
4-bromosalicylaldehyde

: 698982-26-2
5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-3-[2-methoxy-4-(trimethylstannyl)phenyl]-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 1.5 h / Heating / reflux

2: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 16 h / 20 °C

3: household bleach ("CLOROX"6. 15percent sodium hypochlorite ; 10 ML) / tetrahydrofuran / 16 h / 20 °C

4: dmap; triethylamine / dichloromethane / 20 °C

5: hexamethyldistannane / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 3 h / 90 °C

With dmap; hydroxylamine hydrochloride; hexamethyldistannane; sodium carbonate; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetone;