3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole
CAS No.:698982-20-6
Molecular Formula:C₁₇H₂₆BrNO₃Si
Molecular Weight:400.388
Hs Code.:

Synonyms:3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

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Technology Process of 3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

There total 4 articles about 3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 698982-14-8
[3-(4-bromo-2-methoxyphenyl)-4,5-dihydroisoxazol-5-yl]methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 698982-20-6
3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 698982-08-0
4-bromo-2-methoxybenzaldehyde oxime

: 698982-20-6
3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: household bleach ("CLOROX"6. 15percent sodium hypochlorite ; 10 ML) / tetrahydrofuran / 16 h / 20 °C

2: dmap; triethylamine / dichloromethane / 20 °C

With dmap; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 22532-62-3
4-bromosalicylaldehyde

: 698982-20-6
3-(4-bromo-2-methoxyphenyl)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 1.5 h / Heating / reflux

2: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 16 h / 20 °C

3: household bleach ("CLOROX"6. 15percent sodium hypochlorite ; 10 ML) / tetrahydrofuran / 16 h / 20 °C

4: dmap; triethylamine / dichloromethane / 20 °C

With dmap; hydroxylamine hydrochloride; sodium carbonate; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; acetone;