(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

Base Information

Chemical Name:(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate
CAS No.:1256288-29-5
Molecular Formula:C₂₈H₄₀NO₇P
Molecular Weight:533.602
Hs Code.:

Synonyms:(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

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Technology Process of (2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

There total 11 articles about (2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1199613-03-0
(2S,3R)-4-[di-(tert-butyl-oxy)-phosphinyl]-N-(phenylmethoxycarbonyl)-L-valine methyl ester

: 100-39-0
benzyl bromide

: 1256288-29-5
(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

Guidance literature:: (2S,3R)-4-[di-(tert-butyl-oxy)-phosphinyl]-N-(phenylmethoxycarbonyl)-L-valine methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 0 - 20 ℃;

benzyl bromide; With sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1403265-58-6
C₂₁H₃₄NO₇P

: 100-39-0
benzyl bromide

: 1256288-29-5
(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1007/s00726-013-1567-0

Reference yield:

: 1199613-03-0
(2S,3R)-4-[di-(tert-butyl-oxy)-phosphinyl]-N-(phenylmethoxycarbonyl)-L-valine methyl ester

: 1256288-29-5
(2S,3R)-benzyl 2-(((benzyloxy)carbonyl)amino)-4-(di-tertbutoxyphosphoryl)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; sodium hydrogencarbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1007/s00726-013-1567-0