2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone

Base Information

Chemical Name:2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone
CAS No.:199868-84-3
Molecular Formula:C₁₆H₁₅NO₂
Molecular Weight:253.301
Hs Code.:
DSSTox Substance ID:DTXSID401331814
Nikkaji Number:J924.978H
ChEMBL ID:CHEMBL1406917
Mol file:199868-84-3.mol

Synonyms:2-(2-hydroxy-1-phenylethyl)-1-isoindolinone;199868-84-3;2-(2-hydroxy-1-phenylethyl)-3H-isoindol-1-one;Bionet2_000663;Oprea1_230529;MLS001166335;CHEMBL1406917;SCHEMBL23706096;DTXSID401331814;HMS1365O03;HMS2866G03;MFCD01316002;AKOS015992793;SMR000549887;2-(1-Phenyl-2-hydroxyethyl)isoindolin-1-one;4N-042;2-(2-hydroxy-1-phenylethyl)-2,3-dihydro-1H-isoindol-1-one

Suppliers and Price of 2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(2-HYDROXY-1-PHENYLETHYL)-1-ISOINDOLINONE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
2-(2-HYDROXY-1-PHENYLETHYL)-1-ISOINDOLINONE 95.00%
10MG
$ 679.14

American Custom Chemicals Corporation
2-(2-HYDROXY-1-PHENYLETHYL)-1-ISOINDOLINONE 95.00%
1MG
$ 647.61

Total 0 raw suppliers

Chemical Property of 2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone

Chemical Property:

Boiling Point:472.3±45.0 °C(Predicted)
PKA:14.19±0.10(Predicted)
Density:1.271±0.06 g/cm3(Predicted)
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:253.110278721
Heavy Atom Count:19
Complexity:325

Purity/Quality:: 2-(2-HYDROXY-1-PHENYLETHYL)-1-ISOINDOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2=CC=CC=C2C(=O)N1C(CO)C3=CC=CC=C3

Technology Process of 2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone

There total 6 articles about 2-(2-Hydroxy-1-phenylethyl)-1-isoindolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.76%

: 96017-07-1
methyl-2-(1-oxoisoindolin-2-yl)-2-phenylacetate

: 199868-84-3
2-(2-hydroxy-1-phenylethyl)-1-isoindolinone

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 101-41-7
benzeneacetic acid methyl ester

: 199868-84-3
2-(2-hydroxy-1-phenylethyl)-1-isoindolinone

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

2.2: 20 °C

3.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With N-Bromosuccinimide; lithium borohydride; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 37167-62-7,3042-81-7,61139-20-6
bromo-phenyl-acetic acid methyl ester

: 199868-84-3
2-(2-hydroxy-1-phenylethyl)-1-isoindolinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 20 °C

2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

With lithium borohydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;