(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

Base Information

Chemical Name:(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide
CAS No.:925239-38-9
Molecular Formula:C₃₄H₃₇N₇O₃
Molecular Weight:591.713
Hs Code.:

Synonyms:(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

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Chemical Property of (R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

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Technology Process of (R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

There total 11 articles about (R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₄₅N₇O₅

: 925239-38-9
(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃;
DOI:10.1021/jm070024h

Reference yield:

: 956489-57-9
(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate

: 925239-38-9
(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 85 °C

2: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

3: HCl / ethyl acetate / 1 h / 20 °C

4: (benzotriazol-1-yloxy)-tris(dimethylamino)-phosphonium*PF₆; N-methyl-morpholine / CH₂Cl₂ / 2 h

5: HCl / ethyl acetate / 20 °C

With Lawessons reagent; 4-methyl-morpholine; hydrogenchloride; mercury(II) diacetate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;
DOI:10.1021/jm070024h

Reference yield:

: 937247-19-3
(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

: 925239-38-9
(R)-N-(1-(5-((1H-indol-3-yl)methyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)-2-amino-2-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1: mercury(II) acetate / tetrahydrofuran / 48 h / 20 °C

2: HCl / ethyl acetate / 1 h / 20 °C

3: (benzotriazol-1-yloxy)-tris(dimethylamino)-phosphonium*PF₆; N-methyl-morpholine / CH₂Cl₂ / 2 h

4: HCl / ethyl acetate / 20 °C

With 4-methyl-morpholine; hydrogenchloride; mercury(II) diacetate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm070024h