(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

Base Information

• Chemical Name: (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate
• CAS No.: 937247-19-3
• Molecular Formula: C₂₅H₃₁N₃O₄S
• Molecular Weight: 469.605

Synonyms:(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

Chemical Property of (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

Chemical Property:

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Technology Process of (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate

There total 5 articles about (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate (937247-19-3)

Guidance literature:

Reference yield: 88.0%

2,4-Dimethoxybenzylamine (20781-20-8) + Boc-D-Trp-OH (5241-64-5) → (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate (937247-19-3)

Guidance literature:

2,4-Dimethoxybenzylamine; Boc-D-Trp-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

With Lawessons reagent; In 1,2-dimethoxyethane; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2010.03.037

Reference yield: 78.0%

(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate (956489-57-9) → (R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate (937247-19-3)

Guidance literature:

With Lawessons reagent; In 1,2-dimethoxyethane; at 85 ℃; for 2h;

DOI:10.1021/jm0704550

upstream raw materials:

(R)-tert-butyl 1-(2,4-dimethoxybenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate

2,4-Dimethoxybenzylamine

Boc-D-Trp-OH

Downstream raw materials:

C₃₅H₃₈N₆O₄

C₃₇H₄₂N₆O₄

(R)-tert-butyl 1-(4-(2,4-dimethoxybenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate

C₃₃H₃₇N₅O₄

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