(2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone

Base Information

• Chemical Name: (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone
• CAS No.: 1454290-38-0
• Molecular Formula: C₂₂H₂₅F₂N₇O
• Molecular Weight: 441.484
• Mol file: 1454290-38-0.mol

Synonyms:(2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone

Chemical Property of (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone

There total 11 articles about (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

2-chloro-4,6-dimethoxy-1 ,3,5-triazine (3140-73-6) + 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid (956317-36-5) + (±)5-chloro-N-((4,4-difluoropiperidin-2-yl)methyl)pyridin-2-amine (1454291-19-0) → (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone (1454290-38-0)

Guidance literature:

2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid; With 4-methyl-morpholine; In 1,4-dioxane; at 25 ℃; for 0.5h;

(±)5-chloro-N-((4,4-difluoropiperidin-2-yl)methyl)pyridin-2-amine; In 1,4-dioxane; at 80 ℃; for 3h;

Reference yield:

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid (956317-36-5) + (±) N-((4,4-difluoropiperidin-2-yl)methyl)-4,6-dimethylpyrimidin-2-amine (1454291-22-5) → (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone (1454290-38-0)

Guidance literature:

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,4-dioxane; at 25 ℃; for 0.5h;

(±) N-((4,4-difluoropiperidin-2-yl)methyl)-4,6-dimethylpyrimidin-2-amine; In 1,4-dioxane; at 80 ℃; for 3h;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → (2-(((4,6-dimethylpyrimidin-2-yI)amino)methyl)-4,4-difluoropiperidin-1-yl)(5-methyl-2-(2H-1 ,2,3-triazol-2-yl)phenyl)methanone (1454290-38-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / -40 - -20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether / -78 - -40 °C

3.1: acetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

5.1: 4-methyl-morpholine / 1,4-dioxane / 0.5 h / 25 °C

5.2: 3 h / 80 °C

With 4-methyl-morpholine; N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; sec.-butyllithium; acetic acid; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; dichloromethane;

upstream raw materials:

(±) tert-butyl 4,4-difluoro-2-formylpiperidine-1-carboxylate

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

2-(2H-1,2,3-triazol-2-yl)-5-methylbenzoic acid

(±)5-chloro-N-((4,4-difluoropiperidin-2-yl)methyl)pyridin-2-amine