methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

Base Information

Chemical Name:methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate
CAS No.:1283715-45-6
Molecular Formula:C₂₃H₂₅N₃O₃
Molecular Weight:391.47
Hs Code.:

Synonyms:methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

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Chemical Property of methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

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Technology Process of methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

There total 3 articles about methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1239274-82-8
methyl 2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-3-oxoheptanoate

: 64-19-7,77671-22-8
acetic acid

: 1283715-45-6
methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

Guidance literature:: methyl 2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-3-oxoheptanoate; With ammonium acetate; acetic acid; In toluene; for 1h; Reflux;

acetic acid; at 0 - 70 ℃; for 2h;

Reference yield:

: 39815-78-6
methyl 3-oxoheptanoate

: 1283715-45-6
methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran / 23 h / Reflux; Inert atmosphere

2.1: ammonium acetate; acetic acid / toluene / 1 h / Reflux

2.2: 2 h / 0 - 70 °C

With ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; toluene;

Reference yield:

: 154352-38-2
2-[5-(bromomethyl)pyridin-2-yl]benzonitrile

: 1283715-45-6
methyl (Z)-3-acetamido-2-{[6-(2-cyanophenyl)pyridin-3-yl]methyl}-2-heptenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; lithium chloride / tetrahydrofuran / 23 h / Reflux; Inert atmosphere

2.1: ammonium acetate; acetic acid / toluene / 1 h / Reflux

2.2: 2 h / 0 - 70 °C

With ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; toluene;